Search results for "Locomotor sensitization"

showing 3 items of 3 documents

Increased ethanol consumption after interruption of fat bingeing

2018

There is a marked comorbidity between alcohol abuse and eating disorders, especially in the young population. We have previously reported that bingeing on fat during adolescence increases the rewarding effects of ethanol (EtOH). The aim of the present work was to study if vulnerability to EtOH persists after cessation of binge eating. OF1 mice binged on fat (HFB: high-fat binge) during adolescence (PND 25-43) and were tested for 15 days after the last access to HFB (on PND 59) using the self-administration paradigm, the conditioned place preference (CPP) and locomotor sensitization to ethanol. Our results showed that after 15 days of cessation of fat ingestion, mice increased their consumpt…

Male0301 basic medicinePhysiologySocial Scienceslcsh:MedicineAlcohol abuseDrug AddictionBiochemistryFatsMicechemistry.chemical_compound0302 clinical medicineCocaineMedicine and Health SciencesPsychologyIngestionPublic and Occupational HealthBulimiaOvereatinglcsh:ScienceMultidisciplinaryOrganic CompoundsLipidsBody FluidsChemistryEating disordersBloodBehavioral PharmacologyPhysical SciencesAnatomymedicine.symptomResearch Articlemedicine.medical_specialtyAdolescentAlcohol DrinkingSubstance-Related DisordersAddiction03 medical and health sciencesAlkaloidsRecreational Drug UseInternal medicineMental Health and Psychiatrymental disordersmedicineAnimalsHumansNutritionPharmacologyEthanolEthanolBinge eatingBiological Locomotionbusiness.industryOrganic Chemistrylcsh:RChemical CompoundsBiology and Life Sciencesmedicine.diseaseDietary FatsConditioned place preferenceDietLocomotor sensitization030104 developmental biologyEndocrinologychemistryFoodAlcoholslcsh:Qbusiness030217 neurology & neurosurgeryPLOS ONE
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Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine

2020

Prepulse inhibition (PPI) of the startle reflex is a measure of sensory-motor synchronization. A deficit in PPI has been observed in psychiatric patients, especially those with schizophrenia and vulnerable subjects, since the neural bases of this disorder are also involved in the regulation of PPI. Recently, we have reported that baseline PPI levels in mice can predict their sensitivity to the conditioned reinforcing effects of cocaine in the conditioned place preference (CPP) paradigm. Mice with a low PPI presented a lower sensitivity to the conditioned rewarding effects of cocaine; however, once they acquired conditioned preference with a higher dose of the drug, a more persistent associa…

Cognitive NeurosciencecocainePharmacologyBehavioral sensitizationmale and female micelcsh:RC321-57103 medical and health sciencesBehavioral Neuroscience0302 clinical medicineMoro reflexMedicinelcsh:Neurosciences. Biological psychiatry. NeuropsychiatryPrepulse inhibitionOriginal Research030304 developmental biology0303 health sciencesprepulse inhibitionbusiness.industrybehavioral sensitizationmedicine.diseaseConditioned place preferenceendophenotypeLocomotor sensitizationNeuropsychology and Physiological PsychologySchizophreniaEndophenotypebiomarkerBiomarker (medicine)motor effectsbusiness030217 neurology & neurosurgeryFrontiers in Behavioral Neuroscience
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Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

2020

The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early s…

Reflex StartleStartle responseAnhedoniaPhysiologySelf AdministrationWeaningReinforcing effectsMiceBehavioral NeuroscienceAnimal modelCocaineDopamine Uptake InhibitorsMaternal separation with early weaningFemale micemedicineAnimalsPrepulse inhibitionMotivationmedicine.diagnostic_testPrepulse Inhibitionbusiness.industryMaternal Deprivationmedicine.diseaseAnhedonia-like behavioursConditioned place preferenceSubstance abuseDisease Models AnimalLocomotor sensitizationConditioning OperantBiomarker (medicine)FemalePassive avoidancebusinessBehavioural Brain Research
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